Design, syntheses, and SAR studies of carbocyclic analogues of sergliflozin as potent sodium-dependent glucose cotransporter 2 inhibitors
Publication in refereed journal

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其它資訊
摘要Combating diabetes: A small-molecule carbohydrate mimic, pseudo-sergliflozin, was synthesized effectively by a regio- and stereoselective allylic substitution reaction. It was found to be a potent and selective inhibitor of a transporter protein - sodium-dependent glucose cotransporter 2 (SGLT2) - which is responsible for glucose reabsorption in the human body. It could be a lead compound for further development into an antidiabetic agent. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
著者Shing T.K.M., Ng W.-L., Chan J.Y.-W., Lau C.B.-S.
期刊名稱Angewandte Chemie International Edition
出版年份2013
月份8
日期5
卷號52
期次32
出版社John Wiley & Sons Ltd.
出版地United Kingdom
頁次8401 - 8405
國際標準期刊號1433-7851
電子國際標準期刊號1521-3773
語言英式英語
關鍵詞allylation, antidiabetics, carbohydrate mimics, diastereoselectivity, SGLT2

上次更新時間 2020-25-10 於 02:22