Differential detection of Zn2+ and Cd2+ ions by BODIPY-based fluorescent sensors
Publication in refereed journal


摘要Two monostyryl BODIPY derivatives that contain one or two bis(hydroxyamido)amino group(s) as the metal chelator have been prepared. The effects of various metal ions on their electronic absorption and fluorescence properties have been studied in detail in MeCN or in phosphate buffered saline (PBS). The results show that the derivative with two hydroxyamide chains can selectively detect Zn2+ ions in MeCN. The compound and ions bind in a 1:1 stoichiometry with an association constant of 2.2(±0.1) ×104 M-1. The intensity of the fluorescence emission increases remarkably and is substantially blue-shifted from 624 to 572 nm, owing to the inhibition of intramolecular charge transfer, thus allowing its use as a ratiometric fluorescent sensor for Zn2+ ions. The derivative with four hydroxyamide chains behaves differently: It responds selectively toward Cd2+ ions in phosphate buffered saline. The compound and ions bind in a 1:2 stoichiometry, with first and second association constants of 4.4(±0.9)×104 M-1 and 1.3(±0.1) ×104 M-1, respectively. Upon the addition of 80 equivalents of Cd2+ ions, the fluorescence quantum yield increases 15-fold. Both of these compounds exhibit differential sensing of Zn2+ and Cd2+ ions and the associated color changes can be easily seen by the naked eye. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
著者He H., Ng D.K.P.
期刊名稱Chemistry - An Asian Journal
出版社Wiley - V C H Verlag GmbbH & Co.
頁次1441 - 1446
關鍵詞BODIPY, cadmium, fluorescence, sensors, zinc

上次更新時間 2020-16-10 於 03:12