Anti-tumor action of trichosanthin, a type 1 ribosome-inactivating protein, employed in traditional Chinese medicine: A mini review
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AbstractTrichosanthin (TCS) as a midterm abortifacient medicine has been used clinically in traditional Chinese medicine for centuries. Additionally, TCS manifests a host of pharmacological properties, for instance, anti-HIV and anti-tumor activities. TCS has been reported to inhibit cell growth of a diversity of cancers, including cervical cancer, choriocarcinoma, and leukemia/lymphoma, etc. This article purported to review the various anti-tumor activities of TCS and the mechanism of apoptosis it induced in these tumor cells. These research progresses provide an insight into cancer research and treatment as well as disclose new pharmacological properties of the ancient but popular Chinese medicine. © 2013 The Author(s).
All Author(s) ListSha O., Niu J., Ng T.-B., Cho E.Y.-P., Fu X., Jiang W.
Journal nameCancer Chemotherapy and Pharmacology
Detailed descriptionTo ORKTS: doi: 10.1007/s00280-013-2096-y
Volume Number71
Issue Number6
PublisherSpringer Verlag
Place of PublicationGermany
Pages1387 - 1393
LanguagesEnglish-United Kingdom
KeywordsAnti-tumor, Apoptosis, Ribosome-inactivating protein, Trichosanthin (TCS)

Last updated on 2021-12-05 at 02:14