Cross Sectional Survey of Influenza Antibodies before and during the 2009 Pandemic in Shenzhen, China
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AbstractMuch information is available for the 2009 H1N1 influenza immunity response, but little is known about the antibody change in seasonal influenza before and during the novel influenza A pandemic. In this study, we conducted a cross-sectional serological survey of 4 types of major seasonal influenza in March and September 2009 on a full range of age groups, to investigate seasonal influenza immunity response before and during the outbreak of the sH1N1 influenza in Shenzhen - the largest migration city in China. We found that the 0-5 age group had an increased antibody level for all types of seasonal influenza during the pandemic compared to the pre-outbreak level, in contrast with almost all other age groups, in which the antibody level decreased. Also, distinct from the antibodies of A/H3N2, B/Yamagata and B/Victoria that decreased significantly during the 2009 H1N1 pandemic, the antibody of A/H1N1 showed no statistical difference from the pre-outbreak level. The results suggest that the antibodies against the 2009 sH1N1 cross-reacted with seasonal H1N1. Moreover, the 0-5 age group was under attack by both seasonal and 2009 H1N1 influenza during the pandemic, hence vaccination merely against a new strain of flu might not be enough to protect the youngest group. © 2013 Wu et al.
All Author(s) ListWu C.-L., Lu J., Wang M.H., Lv X., Chen Y., Kung H.-F., Zee B., Cheng X.-W., He M.-L.
Journal namePLoS ONE
Year2013
Month1
Day29
Volume Number8
Issue Number1
PublisherPublic Library of Science
Place of PublicationUnited States
ISSN1932-6203
LanguagesEnglish-United Kingdom

Last updated on 2020-03-07 at 01:29