A randomized placebo controlled trial of an innovative herbal formula in the prevention of atherosclerosis in postmenopausal women with borderline hypercholesterolemia
Publication in refereed journal


摘要Background: Danshen (Salvia miltiorrhiza) and Gegen (Radix puerariae) (D&G) are two herbs frequently used for the treatment of angina and other cardiac symptoms in Chinese materia medica. Recent studies have demonstrated their cardio-protective and anti-atherosclerosis effects. Earlier we have conducted two clinical trials in 2004 and 2007 which demonstrated such effects in extremely high risk patients. Study objective: The aim of the study was to demonstrate the safety and effectiveness of D&G in the prevention of atherosclerosis in postmenopausal women with early hypercholesterolemia. Design: The study was designed as a randomized, double-blinded, placebo-controlled trial with a 12-month treatment period. Subject: A population based sample of 165 postmenopausal women aged 47-65 were included in the trial. Only women who experienced menopause for more than 12 months were recruited. Interventions: The eligible subjects were randomized to take the D&G preparation (two capsules), or image-identical placebo capsules (two capsules) daily, in a double-blind and parallel fashion for 12 month. © 2014 Elsevier Ltd.
著者Kwok T., Leung P.C., Lam C., Ho S., Wong C.K., Cheng K.F., Chook P.
期刊名稱Complementary Therapies in Medicine
出版社Churchill Livingstone
出版地United States
頁次473 - 480
關鍵詞Atherosclerosis, Herbal medicine, Hypercholesterolemia, Postmenopausal women, Prevention

上次更新時間 2020-27-09 於 00:42