A randomized placebo controlled trial of an innovative herbal formula in the prevention of atherosclerosis in postmenopausal women with borderline hypercholesterolemia
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AbstractBackground: Danshen (Salvia miltiorrhiza) and Gegen (Radix puerariae) (D&G) are two herbs frequently used for the treatment of angina and other cardiac symptoms in Chinese materia medica. Recent studies have demonstrated their cardio-protective and anti-atherosclerosis effects. Earlier we have conducted two clinical trials in 2004 and 2007 which demonstrated such effects in extremely high risk patients. Study objective: The aim of the study was to demonstrate the safety and effectiveness of D&G in the prevention of atherosclerosis in postmenopausal women with early hypercholesterolemia. Design: The study was designed as a randomized, double-blinded, placebo-controlled trial with a 12-month treatment period. Subject: A population based sample of 165 postmenopausal women aged 47-65 were included in the trial. Only women who experienced menopause for more than 12 months were recruited. Interventions: The eligible subjects were randomized to take the D&G preparation (two capsules), or image-identical placebo capsules (two capsules) daily, in a double-blind and parallel fashion for 12 month. © 2014 Elsevier Ltd.
All Author(s) ListKwok T., Leung P.C., Lam C., Ho S., Wong C.K., Cheng K.F., Chook P.
Journal nameComplementary Therapies in Medicine
Volume Number22
Issue Number3
PublisherChurchill Livingstone
Place of PublicationUnited States
Pages473 - 480
LanguagesEnglish-United Kingdom
KeywordsAtherosclerosis, Herbal medicine, Hypercholesterolemia, Postmenopausal women, Prevention

Last updated on 2022-08-01 at 23:21