A 4-year prospective follow-up study of childhood OSA and its association with BP
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AbstractBackground: Childhood OSA is a prevalent condition associated with raised BP as documented in cross-sectional studies. This study aimed to determine whether baseline or change in OSA severity was associated with ambulatory BP at 4-year follow-up. Methods: Children who participated in our previous OSA prevalence research were invited to undergo a repeat overnight sleep study and 24-h ambulatory BP monitoring in this 4-year follow-up study. BP parameters of subjects with differing baseline OSA severity, that is, obstructive apnea-hypopnea index (OAHI) < 1/h, 1 to 5/h, and > 5/h, were compared. Overweight and normal-weight children were analyzed separately. Results: One hundred eighty-five of 306 subjects (60%) were included in the analysis, of whom 58 were overweight at baseline. Linear increasing trends of wake systolic BP (SBP), wake diastolic BP (DBP), and sleep SBP z scores at follow-up were found across groups of increasing baseline OSA severity in the normal weight but not in the overweight subgroup. After adjusting for BMI z score, baseline OAHI was independently associated with all BP z scores at follow-up but not associated with changes in BP z scores across 4 years. On the other hand, change in OAHI was independently associated with sleep SBP and DBP z scores at follow-up and with changes in sleep SBP and DBP z scores across 4 years. Conclusions: This study provides longitudinal data as additional proof that childhood OSA is associated with elevated BP independent of obesity. © 2014 American College of Chest Physicians.
All Author(s) ListLi A.M., Au C.T., Ng C., Lam H.S., Ho C.K.W., Wing Y.K.
Journal nameChest
Year2014
Month1
Day1
Volume Number145
Issue Number6
PublisherElsevier Inc.
Place of PublicationUnited States
Pages1255 - 1263
ISSN0012-3692
eISSN1931-3543
LanguagesEnglish-United Kingdom

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