Accuracy of18F-fluorodeoxyglucose positron emission tomography/computed tomography for detection of recurrent or metastatic colorectal carcinoma in patients with rising carcinoembryonic antigen levels
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AbstractObjective: A rise in carcinoembryonic antigen level is commonly encountered during follow-up of patients with colorectal carcinoma. This study aimed to evaluate the diagnostic performance of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) studies for detection of recurrent or metastatic colorectal carcinoma in patients with rising carcinoembryonic antigen levels. Methods: Patients with colorectal carcinoma in clinical remission with rising carcinoembryonic antigen levels who underwent PET/CT in Prince of Wales Hospital, Hong Kong from 2008 to 2011 were included. Patient demographics, carcinoembryonic antigen levels, and clinical follow-up data were recorded. Outcomes were determined by histopathological findings or at least 12-month follow-up. Results: Forty-two PET/CT studies of 37 patients (16 men and 21 women; mean [standard deviation] age, 65.8 [11.6] years) were included. Carcinoembryonic antigen levels ranged from 1.8 to 45 μg/l (9 patients had normal carcinoembryonic antigen levels of <5 μg/l, but serial carcinoembryonic antigen measurements showed a rising trend). Among the 42 events, 23 (55%) had a positive final diagnosis. The sensitivity, specificity, and positive and negative predictive values of PET/CT for recurrence or metastases were 91.3%, 895%, 91.3%, and 89.5%. Conclusion: 18F-FDG PET/CT is a useful imaging modality to evaluate recurrence or metastases in patients with colorectal carcinoma in clinical remission but showing rising carcinoembryonic antigen levels. © 2014 Hong Kong College of Radiologists.
All Author(s) ListYu W.L., Wong S.M., Wang K., Ahuja A.T.
Journal nameHong Kong Journal of Radiology
Year2014
Month1
Day1
Volume Number17
Issue Number1
PublisherHong Kong Academy of Medicine Press
Place of PublicationChina
Pages9 - 15
ISSN2223-6619
eISSN2307-4620
LanguagesEnglish-United Kingdom
KeywordsCarcinoembryonic antigen, Colorectal neoplasms, Positron-emission tomography, Tomography, X-ray computed, Whole body imaging

Last updated on 2020-03-07 at 01:39