Comparison of miR-124-3p and miR-16 for early diagnosis of hemorrhagic and ischemic stroke
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AbstractBackground: The present study aimed to investigate and compare plasma concentrations of miR-124-3p and miR-16 as diagnostic markers in acute stroke. Methods: miR-124-3p and miR-16 concentrations in 93 stroke patients were analyzed using real-time polymerase chain reaction. The primary outcome was the differentiation of hemorrhagic and ischemic stroke. Results: Of 93 patients, 74 (79.6%) were diagnosed as ischemic stroke (IS) and 19 (20.4%) were diagnosed as hemorrhagic stroke (HS). Median plasma 124-3p concentrations taken within 24h of symptom onset were higher in HS patients than that in IS patients (3.8×105 vs 2.0×105 copies/ml plasma, p=0.0109), while median miR-16 concentration in IS patients were higher than that in HS patients (1.6×109 vs 1.3×109 copies/ml plasma, p=0.0399). The odds ratio (OR) for discriminating HS and IS with miR-124-3p and miR-16 was 5.37 and 9.75 respectively. Conclusion: Both miR-124-3p and miR-16 are diagnostic markers to discriminate HS and IS. © 2014.
All Author(s) ListLeung L.Y., Chan C.P.Y., Leung Y.K., Jiang H.L., Abrigo J.M., Wang D.F., Chung J.S.H., Rainer T.H., Graham C.A.
Journal nameClinica Chimica Acta
Year2014
Month6
Day10
Volume Number433
PublisherElsevier BV
Place of PublicationNetherlands
Pages139 - 144
ISSN0009-8981
eISSN1873-3492
LanguagesEnglish-United Kingdom
KeywordsDiagnosis, Hemorrhagic stroke, Ischemic stroke, MicroRNA, Plasma

Last updated on 2020-08-08 at 00:38