Sleep quality in efavirenz-treated Chinese HIV patients - comparing between GT and GG genotype of CYP2B6-516 G/T polymorphisms
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摘要Seventy-two adult Chinese HIV-positive treatment-naïve patients were recruited in a study to evaluate prospectively the associations between CYP2B6 516 G/T polymorphisms and sleep quality following treatment with an efavirenz-based regimen. Overall, the patients gave an allelic frequency of 0.3 for CYP2B6 516 T, and a genotype frequency of 9.4% for TT. Compared to GG, GT gave a higher median value of plasma efavirenz level at four weeks (3.77 mg/L vs 2.59 mg/L, p < 0.001) and 12 months (3.57 mg/L vs 2.97 mg/L, p = 0.026). Using generalised estimating equations analysis to track the variance over time, there was poorer Pittsburgh Sleep Quality Index in GT compared to GG, while GT was associated with a higher efavirenz level of >4 mg/L. There was however no difference in the component sleep scores nor was there direct association between sleep quality and plasma efavirenz levels. The results suggested that CYP2B6 genotype was associated with different patterns of sleep problems, further investigation of which is warranted with the objective of optimizing therapy with efavirenz-based regimens. © The Author(s) 2013 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.
著者Lee S.S., To K.W., Lee M.P., Wong N.S., Chan D.P., Li P.C., Cheung S.W., Chan R.C.
期刊名稱International Journal of STD and AIDS
出版年份2014
月份3
日期1
卷號25
期次3
出版社Royal Society of Medicine
出版地United Kingdom
頁次193 - 200
國際標準期刊號0956-4624
電子國際標準期刊號1758-1052
語言英式英語
關鍵詞AIDS, antiretroviral therapy, CYP2B6, efavirenz, HIV, pharmacogenetics, Pittsburgh sleep quality index, sleep quality, therapeutic drug monitoring

上次更新時間 2020-01-12 於 01:08