Cerebral microbleeds as a predictor of 1-year outcome of poststroke depression
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AbstractBackground and Purpose-Cerebral microbleeds (CMBs) are common in stroke survivors and community-dwelling elderly. The clinical significance of CMBs in the outcome of poststroke depression (PSD) is unknown. This study examined the association between the 1-year outcome of PSD and CMBs. Methods-The study population comprised 774 Chinese patients with acute ischemic stroke who were admitted to the acute stroke unit of a university-affiliated regional hospital in Hong Kong. Three and 15 months after the onset of the index stroke, a research assistant administered the locally validated 15-item Geriatric Depression Scale. PSD was defined as a Geriatric Depression Scale score of =7. Of the 213 patients with PSD at the 3-month follow-up, 135 (63.4%) attended the 15-month follow-up, at which time 89 (65.9%) patients remained depressed (nonremitters), and 46 (34.1%) had recovered (remitters). The presence and location of CMBs were evaluated with magnetic resonance imaging. Results-In comparison with the remitters, nonremitters were more likely to have lobar CMBs (18.4% versus 4.3%; P=0.024). Lobar CMBs remained an independent predictor of PSD in the multivariate analysis, with an odds ratio of 4.96 (P=0.039). Conclusions-The results suggest that lobar CMBs may influence the outcome of PSD. The importance of CMBs in the clinical course of depression in stroke survivors warrants further investigation. © 2013 American Heart Association, Inc.
All Author(s) ListTang W.K., Chen Y., Liang H., Chu W.C.W., Mok V.C.T., Ungvari G.S., Wong K.S.
Journal nameStroke
Year2014
Month1
Day1
Volume Number45
Issue Number1
PublisherLippincott Williams & Wilkins Ltd.
Place of PublicationUnited States
Pages77 - 81
ISSN0039-2499
eISSN1524-4628
LanguagesEnglish-United Kingdom
KeywordsDepression, Magnetic resonance imaging, Outcome measures, Stroke

Last updated on 2020-13-08 at 01:43