Cerebral microbleeds as a predictor of 1-year outcome of poststroke depression
Publication in refereed journal

Times Cited
Altmetrics Information

Other information
AbstractBackground and Purpose-Cerebral microbleeds (CMBs) are common in stroke survivors and community-dwelling elderly. The clinical significance of CMBs in the outcome of poststroke depression (PSD) is unknown. This study examined the association between the 1-year outcome of PSD and CMBs. Methods-The study population comprised 774 Chinese patients with acute ischemic stroke who were admitted to the acute stroke unit of a university-affiliated regional hospital in Hong Kong. Three and 15 months after the onset of the index stroke, a research assistant administered the locally validated 15-item Geriatric Depression Scale. PSD was defined as a Geriatric Depression Scale score of =7. Of the 213 patients with PSD at the 3-month follow-up, 135 (63.4%) attended the 15-month follow-up, at which time 89 (65.9%) patients remained depressed (nonremitters), and 46 (34.1%) had recovered (remitters). The presence and location of CMBs were evaluated with magnetic resonance imaging. Results-In comparison with the remitters, nonremitters were more likely to have lobar CMBs (18.4% versus 4.3%; P=0.024). Lobar CMBs remained an independent predictor of PSD in the multivariate analysis, with an odds ratio of 4.96 (P=0.039). Conclusions-The results suggest that lobar CMBs may influence the outcome of PSD. The importance of CMBs in the clinical course of depression in stroke survivors warrants further investigation. © 2013 American Heart Association, Inc.
All Author(s) ListTang W.K., Chen Y., Liang H., Chu W.C.W., Mok V.C.T., Ungvari G.S., Wong K.S.
Journal nameStroke
Volume Number45
Issue Number1
PublisherLippincott Williams & Wilkins Ltd.
Place of PublicationUnited States
Pages77 - 81
LanguagesEnglish-United Kingdom
KeywordsDepression, Magnetic resonance imaging, Outcome measures, Stroke

Last updated on 2021-20-09 at 00:01