Aberrant interhemispheric functional connectivity within default mode network and its relationships with neurocognitive features in cognitively normal APOE ε 4 elderly carriers
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AbstractBackground: Default mode network (DMN) is vulnerable to the effects of APOE genotype. Given the reduced brain volumes and APOE ε 4-related brain changes in elderly carriers, it is less known that whether these changes would influence the functional connectivity and to what extent. This study aimed to examine the functional connectivity within DMN, and its diagnostic value with age-related morphometric alterations considered.

Methods: Whole brain and seed-based resting-state functional connectivity (RSFC) analysis were conducted in cognitively normal APOE ε 4 carriers and matched non-carriers ( N =38). The absolute values of mean correlation coefficients ( z -values) were used as a measure of functional connectivity strength (FCS) between DMN subregions, which were also used to estimate their diagnostic value by receiver-operating characteristic (ROC) curves.

Results: APOE ε 4 carriers demonstrated decreased interhemispheric FCS, particularly between right hippocampal formation (R.HF) and left inferior parietal lobular (L.IPL) ( t =3.487, p <0.001). ROC analysis showed that the FCS of R.HF and L.IPL could differentiate APOE ε 4 carriers from healthy counterparts (AUC value=0.734, p =0.025). Moreover, after adjusting the impact of morphometry, the differentiated value of FCS of R.HF and L.IPL was markedly improved (AUC value=0.828, p =0.002).

Conclusions: Our findings suggest that APOE ε 4 allele affects the functional connectivity within posterior DMN, particularly the atrophy-corrected interhemispheric FCS before the clinical expression of neurodegenerative disease.
Acceptance Date23/03/2017
All Author(s) ListHanna Lu, Suk Ling Ma, Savio Wai Ho Wong, Cindy W. C. Tam, Sheung-Tak Cheng, Sandra S. M. Chan, Linda C. W. Lam
Journal nameInternational Psychogeriatrics
Volume Number29
Issue Number5
Pages805 - 814
LanguagesEnglish-United Kingdom
Keywordsapolipoprotein E, functional connectivity, default mode network, neurocognitive disorder, Alzheimer’s disease

Last updated on 2021-22-06 at 00:42