Efficacy, safety and mechanism of chinese herbal medicines for gestational diabetes mellitus: evidence from meta-analysis, animal and cellular studies.
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AbstractBackground: Although good glycaemic control by dietary modifications, oral hypoglycaemic drugs, and even insulin therapy may reduce complications of gestational diabetes mellitus (GDM), pregnancy outcomes are still not optimal. Chinese herbal medicines (CHM) have been used for thousands of years to treat diabetes in China and most other Asian countries. Many clinical trials have been carried out, but its efficacy, safety and mechanism on GDM are still not clear. objective: To provide evidence of efficacy, safety and mechanism of CHM for GDM. Methods: Meta-analysis of clinical trials to evaluate efficacy and safety of CHM for GDM. Animal, cellular and microarray studies to investigate its therapeutic effects and actions on GDM models. Results: Sufficient qualified clinical trials and participants were included and showed either CHM alone or CHM in combination with other therapies was more effective than other therapies alone to control hyperglycaemic controls and improve pregnancy outcomes. Amongst all CHM, Dwarf Lilyturf Tuber (Ophiopogonis Radix, Maidong) was the most effective CHM to improve glucose intolerance in Lepr diabetic pregnant mice in dose-dependent manner. Fetal resorption, congenital malformation and macrosomia were also reduced. Furthermore polysaccharide extract of Maidong enhanced insulin secretion in Lepr diabetic, high fat diet-induced diabetic mice and MIN6 insulinoma cells by inhibiting NFkB/IL1b inflammatory pathway. Conclusion: This is the first comprehensive studies to provide strong evidence of efficacy, safety and mechanism of CHM for GDM. It will form a national practice guideline of CHM for GDM in the regions. Further studies are needed before promoting to the world.
All Author(s) ListWang C., Tong .Y, Mao D. D., San Lau C. B., Tam W. H.
Name of ConferenceThe 9th International Symposium on Diabetes, Hypertension, Metabolic Syndrome and Pregnancy DIP 2017
Start Date of Conference08/03/2017
End Date of Conference12/03/2017
Place of ConferenceBarcelona
Country/Region of ConferenceSpain
LanguagesEnglish-United States

Last updated on 2018-22-01 at 05:52