Rotavirus vaccine effectiveness against different genotypes circulating in Hong Kong during 2014/15
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摘要Background and aims
Rotavirus vaccine of at least one dose was shown to have 89%-96% effectiveness in preventing hospitalisation from the disease during the 2014/15 rotavirus season in Hong Kong. Here we assess the effectiveness of rotavirus vaccine against different circulating genotypes.

Methods
We conducted a ‘test-negative’ case-control design vaccine effectiveness study in six public hospitals in Hong Kong. Rotavirus G and P genotypes were identified using nested reverse-transcriptase-polymerase chain reaction.

Results
A total of 404 patients were included in the effectiveness study. 73 of 126 (58%) rotavirus-positive patients had the virus G and P genotypes determined. The predominant genotype was G9P[8] (58%), followed by G1P[8] (18%). Among those who were rotavirus-negative, 67 (24%) were vaccinated: 46 had full course Rotarix, 12 full course RotaTeq, 5 partial course Rotarix and 4 partial course of RotaTeq. Rotavirus genotype distribution by vaccination status is shown in the table below.

Vaccinated n (%) Unvaccinated n (%) Vaccine effectiveness 95% Confidence interval

G9P[8] 0 (0) 42 (100) 100 -
   
G1P[8] 0 (0) 13 (100) 100 -
   
Genotypes other than G9P[8] and G1P[8] 1 (6) 17 (94) 81 (-42, 98)
   
Genotypes other than G9P[8] 1 (3) 30 (97) 90 (22, 99)

Rotavirus-negative 67 (24) 211 (76)

Conclusions
We provide further support for the heterotypic protection provided by rotavirus vaccines.

Acknowledgements
This work was supported by the Research Grants Council General Research Fund [CUHK 14111514]. Genotyping was done by Department for Viral Diarrhea, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, China.
著者Yeung KHT, Chan MCW, Chan PKS, Nelson EAS
會議名稱6th Asian Vaccine Conference
會議開始日27.04.2017
會議完結日29.04.2017
會議地點Singapore
會議國家/地區新加坡
出版年份2017
月份4
語言英式英語

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