Low baseline serum 25OHD level is associated with better response of bone qualities to vitamin D supplementation during the peripubertal period in adolescent idiopathic scoliosis
Invited conference paper presented and published in conference proceedings
CUHK Authors
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AbstractIntroduction:
Patients with adolescent idiopathic scoliosis(AIS) have systematic and persistent lowbone mass and abnormal bone qualities. Studies have demonstrated the importance of vitamin Dsupplementation in enhancing bone qualities. Whether adolescents with lower baseline 25-hydroxyvitamin D(25OHD) benefit more from vitamin D supplementation remains unclear. This studyaims to(a) investigate factors that modify the changes of serum 25OHD level in response to vitamin Dsupplementation, and(b) to evaluate the association of baseline serum 25OHD level with increment inbone qualities in response to vitamin D supplementation during the peripubertal period in AIS.Materials and Methods:
Chinese AIS girls(11-14 years old) who completed 2-year supplementation ofvitamin D3(800IU/d) and calcium(600mg/d) were included with data obtained at age sincetreatment(Visit-1), and at one-year(Visit-2) and two-year(Visit-3) follow-ups. Serum 25OHD wasassessed, and bone qualities were evaluated with high-resolution peripheral quantitative computedtomography(HR-pQCT). Results:
A total of 83 girls with AIS(12.75±0.90 years old; Cobb: 25.01±7.45º)were included. Baseline serum 25OHD level was associated with response of serum 25OHD level tovitamin D supplementation(p<0.001). The baseline serum 25OHD level was negatively associated withincrement of total(p=0.028) and cortical(p=0.011) volumetric BMD, and cortical area(p=0.037) fromVisit-1 to Visit-2. Similar changes were shown from Visit-1 to Visit-3.
Discussion and conclusion:
AISpatients with low baseline serum 25OHD levels have greater increment in bone qualities in response to vitamin D supplementation during the peripubertal period. Our findings support vitamin Dsupplementation to AIS patients with vitamin D insufficiency to enhance bone qualities.
Patients with adolescent idiopathic scoliosis(AIS) have systematic and persistent lowbone mass and abnormal bone qualities. Studies have demonstrated the importance of vitamin Dsupplementation in enhancing bone qualities. Whether adolescents with lower baseline 25-hydroxyvitamin D(25OHD) benefit more from vitamin D supplementation remains unclear. This studyaims to(a) investigate factors that modify the changes of serum 25OHD level in response to vitamin Dsupplementation, and(b) to evaluate the association of baseline serum 25OHD level with increment inbone qualities in response to vitamin D supplementation during the peripubertal period in AIS.Materials and Methods:
Chinese AIS girls(11-14 years old) who completed 2-year supplementation ofvitamin D3(800IU/d) and calcium(600mg/d) were included with data obtained at age sincetreatment(Visit-1), and at one-year(Visit-2) and two-year(Visit-3) follow-ups. Serum 25OHD wasassessed, and bone qualities were evaluated with high-resolution peripheral quantitative computedtomography(HR-pQCT). Results:
A total of 83 girls with AIS(12.75±0.90 years old; Cobb: 25.01±7.45º)were included. Baseline serum 25OHD level was associated with response of serum 25OHD level tovitamin D supplementation(p<0.001). The baseline serum 25OHD level was negatively associated withincrement of total(p=0.028) and cortical(p=0.011) volumetric BMD, and cortical area(p=0.037) fromVisit-1 to Visit-2. Similar changes were shown from Visit-1 to Visit-3.
Discussion and conclusion:
AISpatients with low baseline serum 25OHD levels have greater increment in bone qualities in response to vitamin D supplementation during the peripubertal period. Our findings support vitamin Dsupplementation to AIS patients with vitamin D insufficiency to enhance bone qualities.
Acceptance Date15/09/2022
All Author(s) ListKenneth Yang, Wayne Lee, Alec Hung, Jack Cheng, Tsz-Ping Lam
Name of ConferenceThe Hong Kong Orthopaedic Association 2022 Annual Congress
Start Date of Conference05/11/2022
End Date of Conference06/11/2022
Place of ConferenceHong Kong
Country/Region of ConferenceHong Kong
Year2022
LanguagesEnglish-United Kingdom
