Rotavirus vaccine effectiveness in Hong Kong children
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AbstractBackground:
Rotavirus is a common infectious cause of childhood hospitalisation in Hong Kong. Rotavirus
vaccines have been used in the private sector since licensure in 2006 but have not been incorporated in
the government’s universal Childhood Immunisation Programme. This study aimed to evaluate rotavirus
vaccine effectiveness against hospitalisation.

Methods:
This case-control study was conducted in the 2014/2015 rotavirus season in six public hospitals.
Hospitalised acute gastroenteritis patients meeting inclusion criteria were recruited and copies of
their immunisation records were collected. Case-patients were defined as enrolled subjects with stool
specimens obtained in the first 48 h of hospitalisation that tested positive for rotavirus, whereas
control-patients were those with stool specimens obtained in the first 48 h of hospitalisation testing negative
for rotavirus. Vaccine effectiveness for administration of at least one dose of either Rotarix
(GlaxoSmithKline Biologicals) or RotaTeq (Merck Research Laboratories) was calculated as 1 minus
the odds ratio for rotavirus vaccination history for case-patients versus control-patients.

Results:
Among the 525 eligible subjects recruited, immunisation records were seen in 404 (77%) subjects.
31% (162/525 and 126/404) tested positive for rotavirus. In the 404 subjects assessed for vaccine effectiveness,
2.4% and 24% received at least 1 dose of either rotavirus vaccine in case- and control-patients
respectively. The unmatched vaccine effectiveness against hospitalisation for administration of at least
one dose of either rotavirus vaccines was 92% (95% confidence interval [CI]: 75%, 98%). The matched analyses
by age only and both age and admission date showed 96% (95% CI: 72%, 100%) and 89% (95% CI: 51%,
97%) protection against rotavirus hospitalisation respectively.

Conclusions:
Rotavirus vaccine is highly effective in preventing hospitalisation from rotavirus disease in
young Hong Kong children.
Acceptance Date16/08/2016
All Author(s) ListKarene Hoi Ting Yeung, Jacqueline E. Tate, Ching Ching Chan, Martin C.W. Chan, Paul K.S. Chan, Kin Hung Poon, Sylvia Luen Yee Siu, Genevieve Po Gee Fung, Kwok Leung Ng, Iris Mei Ching Chan, Pui Tak Yu, Chi Hang Ng, Yu Lung Lau, E. Anthony S. Nelson
Journal nameVaccine
Year2016
Month9
Day22
Volume Number34
Issue Number41
PublisherElsevier
Pages4935 - 4942
ISSN0264-410X
eISSN1873-2518
LanguagesEnglish-United Kingdom
KeywordsRotavirus, Gastroenteritis, Rotavirus vaccine, Vaccine effectiveness

Last updated on 2020-17-09 at 03:37