Impacts of Camellia kucha and its main chemical components on the lipid accumulation in 3T3-L1 adipocytes
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摘要Camellia kucha, a wild tea plant with potent antioxidant potential, has been consumed as local beverage for a long history. It is featured for the presence of theacrine and low content of caffeine. Interestingly, compared with caffeine showed strong stimulant effect, theacrine showed sedation, hypnoses and promoting memory function. In this study, the anti-adipogenic ability of Kucha tea (KT) and its main components were evaluated in mouse 3T3-L1 cells. The results indicated that KT acted significantly to decrease lipid droplet accumulation. Moreover, KT decreased the expression of major transcription factors of adipogenesis pathway, such as PPAR and C/EBP . KT also decreased the mRNA and protein levels of fatty acid synthase, fatty acid translocase, steroylcoenzyme A desaturase-1, lipoprotein lipase and acetyl-CoA carboxylase-1. Furthermore, KT suppressed the activation of ERK, p38 and JNK.
出版社接受日期22.07.2016
著者Li KK, Wong HL, Hu TY, Zhang C, Han XQ, Ye CX, Leung PC, Cheng BH, Ko CH
期刊名稱International Journal of Food Science and Technology
出版年份2016
月份12
日期1
卷號51
期次12
出版社WILEY-BLACKWELL
頁次2546 - 2555
國際標準期刊號0950-5423
語言英式英語
關鍵詞Anti-adipogenic effect,Camellia kucha,MAPK pathway,theacrine
Web of Science 學科類別Food Science & Technology;Food Science & Technology

上次更新時間 2020-25-11 於 03:13