Impacts of Camellia kucha and its main chemical components on the lipid accumulation in 3T3-L1 adipocytes
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AbstractCamellia kucha, a wild tea plant with potent antioxidant potential, has been consumed as local beverage for a long history. It is featured for the presence of theacrine and low content of caffeine. Interestingly, compared with caffeine showed strong stimulant effect, theacrine showed sedation, hypnoses and promoting memory function. In this study, the anti-adipogenic ability of Kucha tea (KT) and its main components were evaluated in mouse 3T3-L1 cells. The results indicated that KT acted significantly to decrease lipid droplet accumulation. Moreover, KT decreased the expression of major transcription factors of adipogenesis pathway, such as PPAR and C/EBP . KT also decreased the mRNA and protein levels of fatty acid synthase, fatty acid translocase, steroylcoenzyme A desaturase-1, lipoprotein lipase and acetyl-CoA carboxylase-1. Furthermore, KT suppressed the activation of ERK, p38 and JNK.
Acceptance Date22/07/2016
All Author(s) ListLi KK, Wong HL, Hu TY, Zhang C, Han XQ, Ye CX, Leung PC, Cheng BH, Ko CH
Journal nameInternational Journal of Food Science and Technology
Year2016
Month12
Day1
Volume Number51
Issue Number12
PublisherWILEY-BLACKWELL
Pages2546 - 2555
ISSN0950-5423
LanguagesEnglish-United Kingdom
KeywordsAnti-adipogenic effect,Camellia kucha,MAPK pathway,theacrine
Web of Science Subject CategoriesFood Science & Technology;Food Science & Technology

Last updated on 2020-11-08 at 05:17