Cellular Interactions and Formation of an Epithelial "Nanocoating-Like Barrier" with Mesoporous Silica Nanoparticles
Publication in refereed journal

香港中文大學研究人員

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摘要Oral mucosa as the front-line barrier in the mouth is constantly exposed to a complex microenvironment with multitudinous microbes. In this study, the interactions of mesoporous silica nanoparticles (MSNs) with primary human gingival epithelial cells were analyzed for up to 72 h, and their diffusion capacity in the reconstructed human gingival epithelia (RHGE) and porcine ear skin models was further assessed at 24 h. It was found that the synthesized fluorescent mesoporous silica nanoparticles (RITC-NPs) with low cytotoxicity could be uptaken, degraded, and/or excreted by the human gingival epithelial cells. Moreover, the RITC-NPs penetrated into the stratum corneum of RHGE in a time-dependent manner, while they were unable to get across the barrier of stratum corneum in the porcine ear skins. Consequently, the penetration and accumulation of RITC-NPs at the corneum layers of epithelia could form a nanocoating-like barrier. This preliminary proof-of-concept study suggests the feasibility of developing nanoparticle-based antimicrobial and anti-inflammatory agents through topical application for oral healthcare.
出版社接受日期19.10.2016
著者Li X, Pang KY, Ng TW, Leung PC, Zhang CF, Leung KCF, Jin LJ
期刊名稱Nanomaterials
出版年份2016
月份10
日期1
卷號6
期次11
出版社MDPI AG
國際標準期刊號2079-4991
語言英式英語
關鍵詞nanoparticles,human gingival epithelium,coating,stratum corneum
Web of Science 學科類別Nanoscience & Nanotechnology;Materials Science, Multidisciplinary;Science & Technology - Other Topics;Materials Science

上次更新時間 2020-25-10 於 02:08