Enhanced Transdermal Permeability via Constructing the Porous Structure of Poloxamer-Based Hydrogel
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AbstractA major concern for transdermal drug delivery systems is the low bioavailability of targeted drugs primarily caused by the skin's barrier function. The resistance to the carrier matrix for the diffusion and transport of drugs, however, is routinely ignored. This study reports a promising and attractive approach to reducing the resistance to drug transport in the carrier matrix, to enhance drug permeability and bioavailability via enhanced concentration-gradient of the driving force for transdermal purposes. This approach simply optimizes and reconstructs the porous channel structure of the carrier matrix, namely, poloxamer 407 (P407)-based hydrogel matrix blended with carboxymethyl cellulose sodium (CMCs). Addition of CMCs was found to distinctly improve the porous structure of the P407 matrix. The pore size approximated to normal distribution as CMCs were added and the fraction of pore number was increased by over tenfold. Transdermal studies showed that P407/CMCs saw a significant increase in drug permeability across the skin. This suggests that P407/CMC with improved porous structure exhibits a feasible and promising way for the development of transdermal therapy with high permeability and bioavailability, thereby avoiding or reducing use of any chemical enhancers.
Acceptance Date15/11/2016
All Author(s) ListWang WY, Hui PCL, Wat E, Ng FSF, Kan CW, Lau CBS, Leung PC
Journal namePOLYMERS
Volume Number8
Issue Number11
PublisherMDPI AG
Pages1 - 12
LanguagesEnglish-United Kingdom
Keywordsenhanced permeability,hydrogel matrix,porous structure,transdermal drug delivery
Web of Science Subject CategoriesPolymer Science;Polymer Science

Last updated on 2021-20-09 at 23:57