Endoscope-assisted magnetic helical micromachine delivery for biofilm eradication in tympanostomy tube
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AbstractOcclusion of the T-tube (tympanostomy tube) is a common postoperative sequela related to bacterial biofilms. Confronting biofilm-related infections of T-tubes, maneuverable and effective treatments are still challenging presently. Here, we propose an endoscopy-assisted treatment procedure based on the wobbling Fe2O3 helical micromachine (HMM) with peroxidase-mimicking activity. Different from the ideal corkscrew motion, the Fe2O3 HMM applies a wobbling motion in the tube, inducing stronger mechanical force and fluid convections, which not only damages the biofilm occlusion into debris quickly but also enhances the catalytic generation and diffusion of reactive oxygen species (ROS) for killing bacteria cells. Moreover, the treatment procedure, which integrated the delivery, actuation, and retrieval of Fe2O3 HMM, was validated in the T-tube implanted in a human cadaver ex vivo. It enables the visual operation with ease and is gentle to the tympanic membrane and ossicles, which is promising in the clinical application.
Acceptance Date22/08/2022
All Author(s) ListYue Dong, Lu Wang, Zifeng Zhang, Fengtong Ji, Tony K. F. Chan, Haojin Yang, Catherine P. L. Chan, Zhengxin Yang, Zigui Chen, Wai Tsz Chang, Jason Y. K. Chan, Joseph J. Y. Sung, Li Zhang
Journal nameScience Advances
Volume Number8
Issue Number40
PublisherAmerican Association for the Advancement of Science: Science Advances / AAAS
Article numbereabq8573
LanguagesEnglish-United States

Last updated on 2024-09-04 at 00:07