A mucoadhesive endoluminal wearable sensory system
Refereed conference paper presented and published in conference proceedings


摘要Bio- or muco-adhesive anchoring is a challenge for the development of advanced gastrointestinal (GI) surgical instruments, endoluminal monitoring devices and drug delivery systems. In this paper, we present a polymeric bio-adhesive film embedded with an optical sensor that can potentially be used to detect gastrointestinal bleeding. Four different formulas of mucoadhesive polymers were synthesized based on various chemical components and concentration combinations, and they were further layered with miniature photoplethymographic (PPG) sensors. The adhesive ability of the proposed mucoadhesive-sensor module was tested by attaching it to the lumen of a porcine stomach and compared amongst the four formulas. pH testing was also implemented to simulate the performance of the film in gastric cavity. To demonstrate the signal quality of this module, we also tested on the skin of five healthy subjects for hours. The observed shear detachment force between mucoadhesive film and porcine stomach tissue of all four formulations ranged from 0.09 to 1.38 N, and the performance of mucoadhesive film in pH 7 and pH 2 were similar. The module can attach firmly onto the skin for 3-10 hours with comparable PPG signal quality to traditional clip-based setup. With the advent of mucosal tissue anchoring by means of bioadhensive film, a wider extent of endoluminal procedures may become feasible. This emerging technology can also help shape the future of in-body wearable devices in the GI tract or other endoluminal cavities.
著者Chan C.K.W., Zheng Y., Siu E.H.L., Yu R., Leung B.H.K., Zhang R., Poon C.C.Y.
會議名稱37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015
期刊名稱Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society
頁次4355 - 4358

上次更新時間 2020-28-10 於 01:06