Host Cell Antimicrobial Responses against Helicobacter pylori Infection: From Biological Aspects to Therapeutic Strategies
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香港中文大學研究人員
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摘要The colonization of Helicobacter pylori (H. pylori) in human gastric mucosa is highly associated with the occurrence of gastritis, peptic ulcer, and gastric cancer. Antibiotics, including amoxicillin, clarithromycin, furazolidone, levofloxacin, metronidazole, and tetracycline, are commonly used and considered the major treatment regimens for H. pylori eradication, which is, however, becoming less effective by the increasing prevalence of H pylori resistance. Thus, it is urgent to understand the molecular mechanisms of H. pylori pathogenesis and develop alternative therapeutic strategies. In this review, we focus on the virulence factors for H. pylori colonization and survival within host gastric mucosa and the host antimicrobial responses against H. pylori infection. Moreover, we describe the current treatments for H. pylori eradication and provide some insights into new therapeutic strategies for H. pylori infection.
著者Zeng J, Xie C, Zhang L, Liu X, Chan MTV, Wu WKK, Chen H
期刊名稱International Journal of Molecular Sciences
出版作品名稱International Journal of Molecular Sciences
出版年份2022
月份9
卷號23
期次18
出版社MDPI
頁次10941
國際標準期刊號1422-0067
電子國際標準期刊號1422-0067
語言英式英語
關鍵詞helicobacter pylori, host cells, antimicrobial responses, antibiotic-resistance
