Associations of epithelial c-kit expression in phyllodes tumours of the breast
Publication in refereed journal

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摘要Background Mammary phyllodes tumours (PT) are rare biphasic neoplasms but have important clinical significance. Both epithelial and stromal components participate in PT development. Despite a number of studies on stromal c-kit in PT, little is known about the role of its epithelial expression. Objective To further evaluate the stromal and epithelial expression of c-kit in a cohort of patients with PT. Method and results Expression of c-kit in both epithelial and stromal components was examined and correlated with histological features in PT. Stromal c-kit expression was associated positively with stromal cellularity (median expression=10.0, 30.0 and 50.0 from mild to severe cellularity; p=0.019). Conversely, a significant negative trend between epithelial c-kit expression with stromal pleomorphism (median expression=55.0, 30.0 and 2.5 from mild to severe pleomorphism; p=0.043) and mitosis (median expression=70.0 and 20.0 for low and high mitosis respectively; p=0.003); and a trend of negative correlation with increased PT grade was found. Despite these reverse associations, epithelial and stromal c-kit expressions were positively correlated with each other. Notably, the correlation of stromal c-kit expression with malignant histological features appeared to be stronger in cases with low epithelial c-kit expression but not in those with high epithelial c-kit expression. Conclusions This study demonstrated the association of epithelial c-kit expression with stromal histological features and stromal c-kit. Interestingly, epithelial c-kit expression affected the strength of the correlation of stromal c-kit with these histological features. These findings provide further evidence of the interaction between the epithelial and stromal components in PT.
著者Tawasil J., Go E.M.L., Tsang J.Y.S., Ni Y.-B., Ko C.-W., Tse G.M.
期刊名稱Journal of Clinical Pathology
詳細描述pii: jclinpath-2015-202921. doi: 10.1136/jclinpath-2015-202921. [Epub ahead of print].
出版年份2015
月份10
日期1
卷號68
期次10
出版社BMJ Publishing Group
出版地United Kingdom
頁次808 - 811
國際標準期刊號0021-9746
電子國際標準期刊號1472-4146
語言英式英語

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