High viral load and respiratory failure in adults hospitalized for respiratory syncytial virus infections
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AbstractA prospective study among adults hospitalized for polymerase chain reaction-confirmed respiratory syncytial virus infections (n = 123) showed frequent occurrence of lower respiratory-tract complications causing respiratory insufficiency (52.8%), requirement for assisted ventilation (16.3%), and intensive care unit admission/death (12.2%). High viral RNA concentration was detected at time of hospitalization, including in patients who presented later than 2 days of illness (day 1-2, 7.29 ± 1.47; day 3-4, 7.28 ± 1.41; day 5-8, 6.66 ± 1.87 log10 copies/mL). RNA concentration was independently associated with risk of complications and respiratory insufficiency (adjusted odds ratio 1.40 per log10 copies/mL increase, 95% confidence interval, 1.03-1.90; P =. 034). Our data indicate the need and provide a basis for clinical research on antiviral therapy in this population.
All Author(s) ListLee N., Chan M.C.W., Lui G.C.Y., Li R., Wong R.Y.K., Yung I.M.H., Cheung C.S.K., Chan E.C.Y., Hui D.S.C., Chan P.K.S.
Journal nameJournal of Infectious Diseases
Year2015
Month1
Day1
Volume Number212
Issue Number8
PublisherUniversity of Chicago Press
Place of PublicationUnited States
Pages1237 - 1240
ISSN0022-1899
eISSN1537-6613
LanguagesEnglish-United Kingdom
Keywordsrespiratory failure, RSV, viral load

Last updated on 2021-13-05 at 01:13