The clinical utility of SUDOSCAN in chronic kidney disease in Chinese patients with type 2 diabetes
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AbstractThere are gaps between recommendations on regular screening for diabetic kidney disease (DKD) and clinical practice especially in busy and low resource settings. SUDOSCAN (Impeto Medical, Paris, France) is a non-invasive technology for assessing sudomotor function using reverse iontophoresis and chronoamperometry which detects abnormal sweat gland function. Vasculopathy and neuropathy share common risk factors and we hypothesized that SUDOSCAN may be used to detect chronic kidney disease (CKD). Between 2012 and 2013, SUDOSCAN was performed in a consecutive cohort of 2833 Hong Kong Chinese adults with type 2 diabetes. Chronic kidney disease was defined as estimated glomerular filtration rate <60 ml/min/1.73m2. In this cross-sectional cohort (mean age 58.6±9.5 years, 55.7% male, median disease duration 8 [interquartile range 3-14] years), 5.8% had CKD. At a cut-off SUDOSCAN-DKD score of 53, the test had sensitivity of 76.7%, specificity of 63.4% and positive likelihood ratio of 2.1 to detect CKD. The area under receiver operating characteristic curve for CKD was 0.75 (95% confidence interval 0.72-0.79). Patients without CKD but low score had worse risk factors and complications than those with high score. We conclude that SUDOSCAN may be used to detect patients at risk of impaired renal function as part of a screening program in Chinese population, especially in outreach or low resource settings.
All Author(s) ListLuk A.O.Y., Fu W.-C., Li X., Ozaki R., Chung H.H.Y., Wong R.Y.M., So W.-Y., Chow F.C.C., Chan J.C.N., Balasubramanyam M.
Journal namePLoS ONE
Year2015
Month8
Day13
Volume Number10
Issue Number8
PublisherPublic Library of Science
Place of PublicationUnited States
ISSN1932-6203
LanguagesEnglish-United Kingdom

Last updated on 2021-16-01 at 01:08