Three different patterns of CD4 recovery in a cohort of Chinese HIV patients following antiretroviral therapy – a five-year observational study
Publication in refereed journal

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摘要To explore the heterogeneity of CD4 responses following highly active antiretroviral therapy, the patterns of CD4 recovery of HIV-1-infected Chinese patients who have been on their first antiretroviral regimen for ≥5 years were analysed. The CD4 trajectories were traced, smoothed and differentiated into three defined profiles. Half (56.3%) were ‘satisfactory responders’, with CD4 gain of >100 cells/μL and a peak of >350 cells/μL, plateauing before the end of Year 5. Thirty-three (24.4%) were ‘continuing responders’ whose CD4 rise persisted at Year 4–5. The remaining 26 (19.3%) were ‘poor responders’. Presentation with AIDS before therapy was common not just among ‘poor’ but also paradoxically the ‘continuing’ responders. While a majority had responded well to antiretroviral therapy, older patients and those with AIDS diagnosis before initiation of therapy may never achieve a satisfactory level even with effective treatment. Categorization of HIV patients by their CD4 trajectory may support the prediction of immunological outcome over time, and ultimately inform treatment choices.
著者Naftalin C.M., Wong N.S., Chan D.P.C., Wong K.H., Reidpath D.D., Lee S.S.
期刊名稱International Journal of STD and AIDS
出版年份2015
月份10
卷號26
期次11
出版社SAGE PUBLICATIONS LTD
出版地United Kingdom
頁次803 - 809
國際標準期刊號0956-4624
電子國際標準期刊號1758-1052
語言英式英語
關鍵詞AIDS, antiretroviral therapy, Asia, CD4 count, HAART, HIV, immunological response, treatment

上次更新時間 2020-01-12 於 01:02