GlnR-mediated regulation of ectABCD transcription expands the role of the GlnR regulon to osmotic stress management
Publication in refereed journal

香港中文大學研究人員
替代計量分析
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其它資訊
摘要Ectoine and hydroxyectoine are excellent compatible solutes for bacteria to deal with environmental osmotic stress and temperature damages. The biosynthesis cluster of ectoine and hydroxyectoine is widespread among microorganisms, and its expression is activated by high salinity and temperature changes. So far, little is known about the mechanism of the regulation of the transcription of ect genes and only two MarR family regulators (EctR1 in methylobacteria and the EctR1-related regulator CosR in Vibrio cholerae) have been found to negatively regulate the expression of ect genes. Here, we characterize GlnR, the global regulator for nitrogen metabolism in actinomycetes, as a negative regulator for the transcription of ectoine/hydroxyectoine biosynthetic genes (ect operon) in Streptomyces coelicolor. The physiological role of this transcriptional repression by GlnR is proposed to protect the intracellular glutamate pool, which acts as a key nitrogen donor for both the nitrogen metabolism and the ectoine/ hydroxyectoine biosynthesis.
著者Shao Z., Deng W., Li S., He J., Ren S., Huang W., Lu Y., Zhao G., Cai Z., Wang J.
期刊名稱Journal of Bacteriology
出版年份2015
月份1
日期1
卷號197
期次19
出版社American Society for Microbiology
出版地United States
頁次3041 - 3047
國際標準期刊號0021-9193
語言英式英語

上次更新時間 2020-21-11 於 01:31