The first reported fracture liaison service for vertebral fractures in China: in a region with one of the longest life expectancies—is muscle the missing gap?
Refereed conference paper presented and published in conference proceedings
CUHK Authors
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AbstractIntroduction: Vertebral fragility fractures are one of the earliest and most common fragility fractures. Up to 50% of
secondary fractures occur 12 to 24 months after the first fragility fracture. The objective of this study was to mplement a dedicated fracture liaison service (FLS) and improve solutions into decreasing imminent fractures for future use nationwide in China.
Methods: A dedicated FLS was initiated in 2016 at our centre. Patients ≥50 years with vertebral compression fractures were recruited. All patients were offered dual-energy X-ray absorptiometry (DXA) investigation and given education and fall prevention advice. Patients were treated with calcium and vitamin D supplements and denosumab injections and followed up at baseline, 6, 12, 18 and 24 months. The primary outcome was the imminent fracture rate, or the re-fracture rate occurring within 2 years of the initial vertebral fracture.
Results: 226 patients (38 males; 188 females) with a mean age of 77.3 ± 8.56 years were recruited into our FLS for vertebral compression fractures over 2 years. 11.1% (25 patients) had a fall within 2 years, in which 1 resulted in a major osteoporotic fracture. The remaining 225 did not suffer from a re-fracture within the 2-year time period.
Conclusion: Current results show that whilst FLS can prevent imminent fracture risk. Patient disability and fall rates
have an area of improvement. Future FLS should incorporate muscle and sarcopenic assessments routinely. Additionally, research on novel interventions would significantly improve patient outcomes.
secondary fractures occur 12 to 24 months after the first fragility fracture. The objective of this study was to mplement a dedicated fracture liaison service (FLS) and improve solutions into decreasing imminent fractures for future use nationwide in China.
Methods: A dedicated FLS was initiated in 2016 at our centre. Patients ≥50 years with vertebral compression fractures were recruited. All patients were offered dual-energy X-ray absorptiometry (DXA) investigation and given education and fall prevention advice. Patients were treated with calcium and vitamin D supplements and denosumab injections and followed up at baseline, 6, 12, 18 and 24 months. The primary outcome was the imminent fracture rate, or the re-fracture rate occurring within 2 years of the initial vertebral fracture.
Results: 226 patients (38 males; 188 females) with a mean age of 77.3 ± 8.56 years were recruited into our FLS for vertebral compression fractures over 2 years. 11.1% (25 patients) had a fall within 2 years, in which 1 resulted in a major osteoporotic fracture. The remaining 225 did not suffer from a re-fracture within the 2-year time period.
Conclusion: Current results show that whilst FLS can prevent imminent fracture risk. Patient disability and fall rates
have an area of improvement. Future FLS should incorporate muscle and sarcopenic assessments routinely. Additionally, research on novel interventions would significantly improve patient outcomes.
Acceptance Date06/11/2021
All Author(s) ListLinus Chee Yeen Lee, Sheung Wai Law, KoKo Ko, Wai Wang Chau, Simon Kwoon Ho Chow, Wing Hoi Cheung, Ronald Man Yeung Wong
Name of ConferenceThe HKOA 41st Annual Congress
Start Date of Conference06/11/2021
End Date of Conference07/11/2021
Place of ConferenceHong Kong
Country/Region of ConferenceHong Kong
Proceedings TitleThe Hong Kong Orthopaedic Association 41st Annual Congress
Year2021
Month11
PublisherHKAM Press
Place of PublicationHong Kong
Article numberFP1.12
Pages36 - 36
LanguagesEnglish-United States
KeywordsFracture, vertebral fracture
