Comparison on the muscle and bone parameters in women with and without vertebral compression fractures
Refereed conference paper presented and published in conference proceedings
全文
沒有全文檔案提供 |
其它資訊
摘要Introduction: Vertebral compression fractures (VCFs) are the most common among all osteoporotic fractures. However, the detailed changes of muscle and bone parameters in VCF patients remains uncertain. Herein, the aim of this study was to investigate the relationship of skeletal muscle mass and bone density in women with vertebral compression fracture (VCF) and its effect on physical function and quality of life.
Methods: 21 female patients with VCFs aged over 60 years old and 20 age-matched women were prospectively recruited. Muscle and bone density were assessed using dual-energy X-ray absorptiometry (DEXA) and body impendence analysis (BIA), respectively. Grip strength was used as functional assessment. The quality of life was assessed using Short-form 12 (SF-12) and Oswestry Disability Index (ODI).
Results: Women with vertebral fractures had significantly lower skeletal muscle mass (SMM) (p<0.01), lower grip strength (p<0.01), and lower bone density (BMD) (p<0.01) when compared with women without fractures. These women with VCF demonstrated higher disability and back pain. Multivariate regression analysis showed that lower SMM and lower BMD at femoral neck were correlated with the occurrence of VCF. Further analysis showed VCF patients with multiple fractures have significantly worsen bone-muscle parameters and more disability than patients with single VCF.
Conclusion: Low BMD and low skeletal muscle mass were found in patients with VCFs which were resulted to the
decrease in quality of life. The presence of multiple VCFs has a negative influence on muscle mass and bone density, which can lead to increase in disability and worsening on the quality of life.
Methods: 21 female patients with VCFs aged over 60 years old and 20 age-matched women were prospectively recruited. Muscle and bone density were assessed using dual-energy X-ray absorptiometry (DEXA) and body impendence analysis (BIA), respectively. Grip strength was used as functional assessment. The quality of life was assessed using Short-form 12 (SF-12) and Oswestry Disability Index (ODI).
Results: Women with vertebral fractures had significantly lower skeletal muscle mass (SMM) (p<0.01), lower grip strength (p<0.01), and lower bone density (BMD) (p<0.01) when compared with women without fractures. These women with VCF demonstrated higher disability and back pain. Multivariate regression analysis showed that lower SMM and lower BMD at femoral neck were correlated with the occurrence of VCF. Further analysis showed VCF patients with multiple fractures have significantly worsen bone-muscle parameters and more disability than patients with single VCF.
Conclusion: Low BMD and low skeletal muscle mass were found in patients with VCFs which were resulted to the
decrease in quality of life. The presence of multiple VCFs has a negative influence on muscle mass and bone density, which can lead to increase in disability and worsening on the quality of life.
出版社接受日期06.11.2021
著者Tsun Kit Lau, Gene Chi Wai Man, Koko Shaau Yiu Ko, Leo Tsz Ching Chau, Hiu Wun Wong, Zongshan Hu, Jack Chun Yiu Cheng, Sheung Wai Law
會議名稱HKOA 41st Annual Congress
會議開始日06.11.2021
會議完結日07.11.2021
會議地點Hong Kong
會議國家/地區香港
會議論文集題名HKOA 41st Annual Congress
出版年份2021
月份11
出版社HKAM
出版地Hong Kong
文章號碼FP7.2
頁次85 - 85
語言美式英語
關鍵詞Muscle, vertebral compression fractures
