Biosynthesized Bandages Carrying Magnesium Oxide Nanoparticles Induce Cortical Bone Formation by Modulating Endogenous Periosteal Cells
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香港中文大學研究人員
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摘要Bone grafting is frequently conducted to treat bone defects caused by trauma and tumor removal, yet with significant medical and socioeconomic burdens. Space-occupying bone substitutes remain challenging in the control of osteointegration, and meanwhile activation of endogenous periosteal cells by using non-space-occupying implants to promote new bone formation becomes another therapeutic strategy. Here, we fabricated a magnesium-based artificial bandage with optimal micropatterns for activating periosteum-associated biomineralization. Collagen was self-assembled on the surface of magnesium oxide nanoparticles embedded electrospun fibrous membranes as a hierarchical bandage structure to facilitate the integration with periosteum in situ. After the implantation on the surface of cortical bone in vivo, magnesium ions were released to generate a pro-osteogenic immune microenvironment by activating the endogenous periosteal macrophages into M2 phenotype and, meanwhile, promote blood vessel formation and neurite outgrowth. In a cortical bone defect model, magnesium-based artificial bandage guided the surrounding newly formed bone tissue to cover the defected area. Taken together, our study suggests that the strategy of stimulating bone formation can be achieved with magnesium delivery to periosteum in situ and the proposed periosteal bandages act as a bioactive media for accelerating bone healing.
出版社接受日期12.09.2022
著者Xu Li, Bingyang Dai, Jiaxin Guo, Yuwei Zhu, Jiankun Xu, Shunxiang Xu, Zhi Yao, Liang Chang, Ye Li, Xuan He, Dick Ho Kiu Chow, Shian Zhang, Hao Yao, Wenxue Tong, To Ngai, Ling Qin
期刊名稱ACS Nano
出版年份2022
月份11
日期22
卷號16
期次11
出版社ACS Publications
出版地USA
頁次18071 - 18089
國際標準期刊號1936-0851
電子國際標準期刊號1936-086X
語言美式英語
關鍵詞magnesium, bone regeneration, periosteal bandage
