Different insulin types and regimens for pregnant women with pre-existing diabetes
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Insulin requirements may change during pregnancy, and the optimal treatment for pre-existing diabetes is unclear. There are several insulin regimens (e.g. via syringe, pen) and types of insulin (e.g. fast-acting insulin, human insulin).

To assess the effects of different insulin types and different insulin regimens in pregnant women with pre-existing type 1 or type 2 diabetes.

Search methods
We searched the Cochrane Pregnancy and Childbirth Group’s Trials Register (30 October 2016), ClinicalTrials.gov (17 October 2016), the WHO International Clinical Trials Registry Platform (ICTRP; 17 October 2016), and the reference lists of retrieved studies.

Selection criteria
We included randomised controlled trials (RCTs) that compared different insulin types and regimens in pregnant women with pre existing diabetes.
We had planned to include cluster-RCTs, but none were identified.We excluded quasi-randomised controlled trials and cross-over trials.
We included studies published in abstract form and contacted the authors for further details when applicable. Conference abstracts were superseded by full publications.

Data collection and analysis
Two review authors independently assessed trials for inclusion, conducted data extraction, assessed risk of bias, and checked for accuracy.
We assessed the quality of the evidence using the GRADE approach.
All Author(s) ListO’Neill SM, Kenny LC, Khashan AS, West HM, Smyth RMD, Kearney PM
Title of PublicationCochrane Database of Systematic Reviews
Volume NumberCD011880
PublisherJohn Wiley & Sons, Ltd.
Place of PublicationUnited Kingdom
Pages1 - 92
LanguagesEnglish-United Kingdom

Last updated on 2021-16-09 at 01:34