The Role of Natural Killer Cells in Human Fertility
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AbstractUterine natural killer (uNK) cells form the major leucocyte population in the endometrium at the time of implantation1 and have received considerable attention in relation to their role in normal implantation and early placental development. Particular interest has been paid to their potential role in pregnancy pathology; there were more than 70 papers published between 2013 and 2015 on the role of uNK cells in recurrent miscarriage (RM) and recurrent implantation failure (RIF). Although several clinical studies have suggested that peripheral blood (PB) natural killer (NK) cells and/or uNK cells are increased in women with RM2–6 and RIF,5,7–9 a meta-analysis10 and systematic review11 failed to provide conclusive data because of significant heterogeneity across the studies arising from the use of different methods to quantify NK cells. An understanding of the role of these cells in reproductive failure and their value in clinical practice will not be established until a consensus is reached on how they should be measured.

In this paper, the data relating to NK cell function will be reviewed and recommendations made regarding the measurement of NK cells in women with reproductive failure.
All Author(s) ListLaird SM , Lash GE, Li TC, Bulmer JN
Series TitleRoyal College of Obstetricians & Gynaecologists - Scientific Impact Paper
Number in Series53
Pages1 - 11
LanguagesEnglish-United Kingdom

Last updated on 2018-22-01 at 00:25