Periosteum-Inspired Membranes Integrated with Bioactive Magnesium Oxychloride Ceramic Nanoneedles for Guided Bone Regeneration
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香港中文大學研究人員
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摘要Guided bone regeneration (GBR) technique using a barrier membrane holds great potential to allow the single-stage reconstruction of critical-sized bone defects. Here, bioactive nanoneedle-like magnesium oxychloride ceramics (MOCs) are synthesized and recruited as an osteoinductive factor within a polycaprolactone-gelatin A (PCL-GelA) membranous matrix to generate a periosteum-mimicking biphasic GBR membrane (PCL-GelA/MOC) to accelerate calvarial defect repair. The PCL-GelA/MOC membrane acts as a shield for defect areas and a reservoir of osteoinductive molecules, which provides a favorable microenvironment for supporting cell proliferation, infiltration, and differentiation. This membrane leads to accelerated osteogenesis and angiogenesis, effectual defect bridging, and significantly enhanced bone regeneration when applied to a 5 mm sized rat calvarial defect. This makes this innovative and multifunctional GBR membrane a suitable candidate for clinical applications with promising curative efficacy.
出版社接受日期15.08.2022
著者Yuwei Zhu, Bingyang Dai, Xu Li, Wei Liu, Jiangpeng Wang, Jiankun Xu, Shunxiang Xu, Xuan He, Shian Zhang, Qian Li, Ling Qin, To Ngai
期刊名稱ACS Applied Materials and Interfaces
出版年份2022
月份9
卷號14
期次35
出版社ACS Publications
出版地USA
頁次39830 - 39842
國際標準期刊號1944-8244
語言美式英語
關鍵詞magnesium oxychloride bioceramic, periosteum-inspired membrane, guided bone regeneration
