Baicalein and genistein act differently on estrogen receptor tor transactivation and apoptosis in MCF-7 cells
Refereed conference paper presented and published in conference proceedings


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AbstractGenistein is a soy isoflavone that has attracted much attention for its chemopreventive properties. Baicalein is a flavone found in Scutellaria species, and its structure is analogous to that of genistein. We examined the antiestrogenicity of the two flavones using a transient transfection model. Our results indicated that baicalein could suppress 17-estradiol–induced transactivation in cells expressing estrogen receptor-, whereas no antagonistic activity was seen with genistein. Cell death assay and flow cytometry analysis demonstrated that baicalein was a stronger apoptosis-inducing agent than genistein. Considering all the criteria tested, baicalein could be a better chemopreventive agent than genistein.
All Author(s) ListPo LS, Chen ZY, Tsang DSC, Leung LK
Name of ConferenceInternational Research Conference on Food, Nutrition, and Cancer.
Start Date of Conference11/07/2002
End Date of Conference12/07/2002
Place of ConferenceWashington, D.C.
Country/Region of ConferenceUnited States of America
Journal nameJournal of Nutrition
Proceedings TitleSupplement: International Research Conference on Food, Nutrition & Cancer
Title of PublicationJOURNAL OF NUTRITION
Year2002
Month11
Day1
Volume Number132
Issue Number11
PublisherAMER INST NUTRITION
Pages3555S - 3555S
ISSN0022-3166
eISSN1541-6100
LanguagesEnglish-United Kingdom
Web of Science Subject CategoriesNutrition & Dietetics;Nutrition & Dietetics;NUTRITION & DIETETICS

Last updated on 2020-28-05 at 04:01