HOXA-10 and E-cadherin expression in the endometrium of women with recurrent implantation failure and recurrent miscarriage
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摘要Objective To compare the expression of HOXA-10 and E-cadherin in the endometrium of women with recurrent implantation failure (RIF), women with recurrent miscarriage (RM), and women with proven fertility (normal control; NC). Design Observational cohort study. Setting University assisted reproductive unit. Patient(s) Fifty women were recruited: 18 NC, 12 unexplained RIF, and 20 RM. Interventions(s) None. Main Outcome Measure(s) Endometrial biopsy was precisely timed 7 days after {LH} surge. The expression of HOXA-10 and E-cadherin were examined by means of immunohistochemistry. H-Scores of staining intensity in the glandular epithelium and stroma were measured. Result(s) HOXA-10 signal was mainly localized in the nuclei of stroma cells and the cytoplasm of glandular epithelium cells. E-Cadherin signal was found only in the cytoplasm of glandular epithelium cells. The HOXA-10 H-scores in the {RIF} group and the {RM} group were significantly lower than in the control group in both the glandular epithelium and stroma. The E-cadherin H-scores in the {RM} group were also significantly lower than in the control group. Interestingly, there was a positive correlation between HOXA-10 and E-cadherin H-scores in all of the women examined. Conclusion(s) There is a positive correlation between levels of HOXA-10 and E-cadherin expression in the endometrium, both of which are significantly reduced in women with {RIF} and {RM} compared with fertile control women. The findings suggest a potential role of HOXA-10 and E-cadherin in the implantation processes and altered expression in women with reproductive failure.
出版社接受日期09.09.2016
著者Yang Yihua, Chen Xiaoyan, Saravelos Sotirios H., Liu Yingyu, Huang Jin, Zhang Jiamiao, Li Tin Chiu
期刊名稱Fertility and Sterility
出版年份2017
月份1
卷號107
期次1
出版社Elsevier Science Inc
出版地United States
頁次136 - 143.e2
國際標準期刊號0015-0282
電子國際標準期刊號1556-5653
語言美式英語
關鍵詞Recurrent implantation failure, recurrent miscarriage, HOXA-10, E-cadherin

上次更新時間 2021-07-05 於 11:19