Recent Patents of Complementary and Alternative Medicine for Allergic Rhinitis
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摘要Allergic rhinitis (AR) is a common respiratory disease affecting both adults and children worldwide. Affected patients may experience nasal congestion/stuffiness, rhinorrhea (anterior and/or posterior), nasal/ nasopharyngeal itching and sneezing. Allergen avoidance is the principal step in the management. Nasal saline irrigation to remove allergen (s) in the nose is a useful adjunctive therapy in the management of moderate to severe AR. Symptomatic relief and improved quality of life may be achieved in the majority of patients with appropriate pharmacotherapy. Mild-to-moderate cases are usually managed with either an oral second generation antihistamine or an intranasal corticosteroid. More severe cases may require treatment with an intranasal corticosteroid in combination with various oral medications. Patients who require medications for more than 6 months per year or have intolerable side effects from pharmacotherapy can be considered for immunotherapy. A wide range of complementary and alternative medicines (CAM) have also been proposed. This overview evaluates the evidence of use of CAM for AR. Some methods including acupuncture and herbal medicine have supportive evidence, but the efficacy of other CAM is controversial. Conversely, possible side effects of different modalities are often inadequately documented. The herbal formulae include Butterbur, Nigella sativa, Shi-Bi-Lin, Polyherbal formula, Grapeseed extract, Rosmarinic acid, Spirulina, Biminne, and Bhu-zhong-yi-qi-tong. Further research is needed to assess the efficacy and safety before they are employed in treating AR. This review article also discusses recent CAM patents for use in AR, which are exclusively traditional Chinese medicine (TCM) concoctions primarily for oral consumption but two as topical spray. Only 8 pertinent patents, all TCM compositions for treating AR and registered in 2014, were obtained. Description about their efficacy is impressive but objective outcome evaluation tools are lacking.
著者Hon KL, Fung CK, Leung AK, Lam HS, Lee SL
期刊名稱Recent Patents on Inflammation and Allergy Drug Discovery
出版年份2015
卷號9
期次2
出版社Bentham Science Publishers Ltd.
頁次107 - 119
國際標準期刊號1872-213X
電子國際標準期刊號2212-2710
語言美式英語
關鍵詞Allergen avoidance, allergic rhinitis, combination therapy, complementary and alternative medicine, hay fever, herbs, immunotherapy, pharmacotherapy, intranasal corticosteroid, oral antihistamine, randomized trials, systematic reviews, traditional Chinese medicine.

上次更新時間 2020-28-09 於 23:57