Association between statin use and change in grip strength among community dwelling older men and women from Hong Kong MrOs cohort study
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AbstractAims: To examine the relationship between statin use and grip strength in older adults.
Methods: Prospectively collected data from Mr and Ms Os (Hong Kong) Cohort Study was analyzed. At baseline, 2000 older men and 2000 older women were recruited in 2001– 2003. They were followed every 2 years for 6 years. In this analysis, continuous statin users in the first 2 years were compared with non-users. The outcome measures included hand grip strength (kg/y), chair stand time and walking speed. Analyses were conducted separately for males and females.
Results: 2881 subjects (statin users male n=53, female n = 71) were included in the analysis, mean age 72.49 y. 1434 (49.77 %) were male. There was no difference (P > 0.05) in baseline grip strength between users and non-users of statin. Moreover, There were no differences (P > 0.05) between chair stand time and walking speed in users and non-users of statin at baseline and follow up study. However, adjusted grip strength decreased in year two follow up (mean decreased 1.4528 kg/y in statin users and 0.7569 kg/y in non-statin users) with significant between group differences in male (P = 0.035) but not in female (P>0.05).
Conclusion: Maintenance statin therapy is associated with more decline of grip strength in older male adults.
Acceptance Date05/08/2016
All Author(s) ListLiuying Zhu, Jason Leung, Timothy Chi Yui Kwok
Journal nameOsteoporosis International
Detailed descriptionIOF Regionals: 6th Asia-Pacific Osteoporosis Meeting, 4--6 November 2016, Singapore

ISSN: 0937-941X (Print) 1433-2965 (Online)
Abstract as Osteoporos Int (2016) 27 (Suppl 3):S699–S708
Volume Number27
Issue Number3 Supplement
PublisherSpringer Verlag (Germany)
PagesS700 - S700
LanguagesEnglish-United Kingdom

Last updated on 2020-19-09 at 03:23