Impaired Osteocyte Differentiation and Functional Expression of Sclerostin in Adolescent Idiopathic Scoliosis (AIS) in a 3D Culture Mode l- A New Novel Finding
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AbstractThis is the first study to illustrate the impaired osteocytogenesis in AIS with an in vitro 3D model. The result highlighted that AIS expressed reduced representative osteocyte markers at mRNA and protein level during osteoblast to osteocyte differentiation process. Current investigation provided a novel mechanism might contribute to the observed unique bone quality and bone metabolism profile in AIS.


We hypothesized that the ultrastructural change of osteocytes and LCN in AIS might be attributed to the abnormal osteocytogenesis (differentiation process from osteoblasts to osteocytes).


With an in vitro 3D culture model, we here compared the osteocytogenic potential of primary osteoblasts culture from AIS Vs controls.

All Author(s) ListJiajun Zhang, Wayne Lee, Huanxiong Chen,Elisa MS Tam, Gene Chi Wai Man, Tsz Ping Lam, Yong Qiu, Jack C.Y. Cheng
Name of ConferenceScoliosis Research Society 51st Annual Meeting & Course
Start Date of Conference21/09/2016
End Date of Conference24/09/2016
Place of ConferencePrague, Czech Republic
Country/Region of ConferenceCzech Republic
LanguagesEnglish-United Kingdom

Last updated on 2021-17-02 at 14:24