Thiourea/sodium periodate-induced rapid formation of polydopamine coatings under acidic conditions
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AbstractDopamine has been widely used as a simple building block for surface modification of virtually any material surfaces. Until now, a few methods have been developed for improving the deposition rate of polydopamine (PDA) coatings, such as electrochemically driven deposition, UV irradiation, and the utilization of strong oxidants. Although the above mentioned methods have been proved that they can even trigger the polymerization of dopamine under weak acidic
conditions, the deposition rate is very slow, especially compared with their satisfactory performances in neutral or alkaline solutions. In addition, long-time immersion in the strong oxidants solutions may be harmful to some
oxidant sensitive materials. Also some substrates are not suitable for modification by dopamine under alkaline conditions, such as pH sensitive gel, pH sensitive filter membrane or other alkaline corrosive materials. Therefore,
looking for a method for the rapid formation of PDA coatings under acidic conditions is still a tremendous challenge.
In order to solve this problem, N,N'-dimethylthiourea/sodium periodate system was used to induce the rapid formation of polydopamine coatings at acidic pH. Unlike the amino groups (pKa ~10) that are protonated under acidic conditions, the thiourea (pKa ~-1) groups are reactive towards the catechol derivatives under acidic conditions due to low pKa value. So the thiourea group can act as an excellent nucleophile to react with quinone via Michael addition. The deposition rate of PDA coatings through this method is about 44 nm per hour, even comparable to the PDA deposition rate induced by strong oxidants at basic pH, while the sodium periodate-induced deposition rate is only about 1.3 nm per hour at the same acidic condition. Also, the N,N'-dimethylthiourea/sodium periodate-induced PDA coatings show high uniformity, enhanced chemical stability and good cell biocompatibility.
Acceptance Date31/05/2016
All Author(s) ListPengchao ZHAO, Yang XU, Liming BIAN
Name of Conference2016 Tissue Engineering and Regenerative Medicine International Society- Asia Pacific Meeting (TERMIS-AP 2016)
Start Date of Conference03/09/2016
End Date of Conference06/09/2016
Place of ConferenceTAIPEI
Country/Region of ConferenceTaiwan
LanguagesEnglish-United States

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