Diffusion-weighted imaging of nasopharyngeal carcinoma to predict distant metastases
Publication in policy or professional journal

Times Cited
Web of Science8WOS source URL (as at 15/09/2021) Click here for the latest count
Altmetrics Information

Other information
AbstractOur study aimed to identify diffusion-weighted imaging (DWI) parameters obtained from primary nasopharyngeal carcinoma (NPC) at initial presentation, that can predict patients at risk of distant metastases. One hundred and sixty-four patients underwent pretreatment magnetic resonance imaging and DWI. The apparent diffusion coefficient (ADC)mean, ADCskewness, and ADCkurtosis were obtained by histogram analysis. Univariate and multivariate analyses of these ADC parameters together with primary volume (PV), nodal volume (NV), T stage, N stage and presence of locoregional relapse (LRR) were compared between patients with distant metastases (DM+) and patients without distant metastases (DM−) at 5 years using logistic regression. Twenty-eight out of 164 patients (17.1 %) were DM+ (2.5–60 months) and 136/164 patients were DM− (61.2–119.4 months). Compared to DM− patients, the primary tumour of DM+ patients showed significantly lower ADCskewness (ADC values with the greatest frequency were higher) (p = 0.041), and higher PV (p = 0.022), NV (p < 0.01), T stage (p = 0.023), N stage (p < 0.01) and LRR (p < 0.01). On multivariate analysis the ADCskewness was no longer significant (p = 0.120) and only NV and LRR were independent predictors for DM+ (p = 0.023 and 0.021, respectively). DWI showed that compared to DM− patients, DM+ patients had a significantly lower primary tumour ADCskewness, but at initial presentation NV was the only independent predictor of DM.
Acceptance Date03/10/2016
All Author(s) ListQi-Yong Ai, Ann D. King, Benjamin King Hong Law, David Ka-Wai Yeung, Kunwar S. Bhatia, Jing Yuan, Anil T. Ahuja, Lok Yiu Sheila Wong, Brigette B. Ma, Frankie Kwok Fai Mo, Michael K. M. Kam
Journal nameEuropean Archives of Oto-Rhino-Laryngology
Volume Number274
Issue Number2
Pages1045 - 1051
LanguagesEnglish-United Kingdom
KeywordsDiffusion-weighted imaging, Distant metastases, Magnetic resonance imaging, Nasopharyngeal carcinoma

Last updated on 2021-16-09 at 01:28