Changes of Language Function in Aphasic Stroke Survivors Receiving Bilateral Theta Burst Stimulation
Refereed conference paper presented and published in conference proceedings


摘要Research Objectives: To investigate the potential therapeutic effect of consecutive suppressive-facilitatory TBS in Chinese post-stroke patients with aphasia.
Design: Intervention study: randomized controlled trial.
Setting: General hospital.
Participants: Consecutive stroke survivors visiting Department of Speech Therapy (ST) and acute patients admitted in stroke unit were selected according to the following inclusion criteria: 1) CT or MRI confirming 7-21 days after ictus of a first-ever ischemic stroke or more than three months after stroke onset and only lesion in LMCA territory; 2) adult, right-handed, native Chinese speaker; 3) aphasia recognized in neurological assessment; 4) recordable motor evoked potential of left first dorsal interosseous muscle (FDI). Twenty-one participants were recruited and allocated to three different intervention groups with matched gender, educational background, stroke types and language function at baseline.
Interventions: International 10-20 electroencephalogram system was adapted for TBS localization. Dual-hemispheric TBS consisted of continuous TBS over right hemisphere (between electrodes C4 and F8, 40 seconds) followed by intermittent TBS over left hemisphere (between electrodes C3 and F7, 192 seconds) immediately. Group A (nZ6) received dual-hemispheric TBS plus 30 minutes conventional one-to-one speech therapy. Group B (nZ5) received dual-hemispheric TBS only. Group C (nZ10) received 30 minutes conventional one-to-one speech therapy only.
Main Outcome Measure(s): We assessed language ability by Chinese version of Western Aphasic Battery at baseline and after 10 sessions of daily intervention.
Results: Language ability was improved significantly in all three groups after intervention (paZ0.028, pbZ0.005, pcZ0.043, non-parametric test for two related samples). No difference in therapeutic effects was found among three groups (non-parametric test for three independent samples).
Conclusions: Sequential TBS individually is as effective as treatment by ST only and combining TBS with ST in the Chinese post-stroke patients with aphasia.
著者Weijia HE, Kathy Yuet Sheung LEE, Thomas Wai Hong LEUNG, Howan LEUNG, Qingsu ZHANG, Lawrence Ka Sing WONG
會議名稱American Congress of Rehabilitation Medicine 93rd Annual Conference: Progress in Rehabilitation Research
會議論文集題名Archives of Physical Medicine and Rehabilitation
頁次e9 - e9
關鍵詞Aphasia, Theta burst stimulation, Stroke

上次更新時間 2020-22-11 於 00:19