Anti-influenza virus effect of aqueous extracts from Chinese herbs
Invited conference paper presented and published in conference proceedings

香港中文大學研究人員

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摘要Annual influenza epidemic is estimated to cause 3 to 5 million cases of severe illness, and claims more than
250000 deaths every year. Influenza virus undergoes antigenic variations. Many strains of influenza virus have developed resistance against the existing anti-influenza drugs, thus it is essential to develop new drugs against this
virus.

With a 3000-year history, traditional Chinese Medicine (TCM) has its own unique advantages over modern medicine and has historically been invaluable as a source of therapeutic agents. Empirical knowledge based on the ethnomedical benefits of plants, coupled with bioassay-guided fractionation and isolation, has the potential to identify novel antivirals that could be used against influenza.

In this study, we used a range of bioassays, such as cytopathic assay, plaque reduction assay and real-time
reverse transcription-PCR assay, to screen aqueous extracts of fifty TCM for antiviral activity against influenza virus. Four most potential extracts were found to be non-toxic in mouse based on maximum-tolerated-dose method, and
exhibited in vitro viral inhibition against A/WSN/33 (H1N1) (Figure 1) and A/Puerto Rico/8/1934 (Figure 2). Specific
fractions of some potential extracts isolated by D101 macroporous absorptive resin had an increased potency. Work is being carried out to sub-fractionation and isolating pure compounds n vivo efficacy using influenza virus infected mouse model will be conducted.






























Acknowledgement:
Health and Medical Research Fund (project no. 10090022) and Area of Excellence Grant Scheme
(AoE M12-06).

著者Tianbo Zhang, Chris Ka Pun Mok, Pang Chui Shaw
會議名稱The 15th Meeting of Consortium for Globalization of Chinese Medicine
會議開始日22.08.2016
會議完結日26.08.2016
會議地點Tai Pei
會議國家/地區台灣
出版年份2016
月份8
出版地Taipei
語言美式英語

上次更新時間 2018-22-01 於 09:23