3′untranslated regions of tumor suppressor genes evolved specific features to favor cancer resistance
Publication in refereed journal
香港中文大學研究人員
全文
引用次數
替代計量分析
.
其它資訊
摘要Cancer-related genes have evolved specific genetic and genomic features to favor tumor suppression. Previously we reported that tumor suppressor genes (TSGs) acquired high promoter CpG dinucleotide frequencies during evolution to maintain high expression in normal tissues and resist cancer-specific downregulation. In this study, we investigated whether 3′untranslated regions (3′UTRs) of TSGs have evolved specific features to carry out similar functions. We found that 3′UTRs of TSGs, especially those involved in multiple histological types and pediatric cancers, are longer than those of non-cancer genes. 3′UTRs of TSGs also exhibit higher density of binding sites for RNA-binding proteins (RBPs), particularly those having high affinities to C-rich motifs. Both longer 3′UTR length and RBP binding sites enrichment are correlated with higher gene expression in normal tissues across tissue types. Moreover, both features together with the correlated N6-methyladenosine modification and the extent of protein-protein interactions are positively associated with the ability of TSGs to resist cancer-specific downregulation. These results were successfully validated with independent datasets. Collectively, these findings indicate that TSGs have evolved longer 3′UTR with increased propensity to RBP binding, N6-methyladenosine modification and protein-protein interactions for optimizing their tumor-suppressing functions.
著者Huang D, Wang X, Huang Z, Liu Y, Liu X, Gin T, Wong SH, Yu J, Zhang L, Chan MTV, Chen H, Wu WKK
期刊名稱Oncogene
出版年份2022
月份6
日期3
卷號41
期次23
出版社Springer
頁次3278 - 3288
國際標準期刊號0950-9232
電子國際標準期刊號1476-5594
語言英式英語
