Smad3 Promotes Cancer-Associated Fibroblasts Generation via Macrophage–Myofibroblast Transition (Adv. Sci. 1/2022)
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AbstractIn article number 2101235 Philip Chiu-Tsun Tang, Patrick Ming-Kuen Tang, Hui-Yao Lan, and co-workers discovered that tumor-associated macrophages are capable for de novo generating pathogenic cancer-associated fibroblasts via a direct mechanism macrophage-myofibroblast transition (MMT), representing a novel therapeutic target in the tumor microenvironment of solid cancers. Here, the macrophages undergoing MMT were coexpressing CAF (α-SMA, red) and macrophage marker (F4/80, green) with nuclei staining (blue), visualized by immunofluorescence with an experimental Lewis lung carcinoma (LLC) model.
All Author(s) ListPhilip Chiu-Tsun Tang, Jeff Yat-Fai Chung, Vivian Wei-wen Xue, Jun Xiao, Xiao-Ming Meng, Xiao-Ru Huang, Shuang Zhou, Alex Siu-Wing Chan, Anna Chi-Man Tsang, Alfred Sze-Lok Cheng, Tin-Lap Lee, Kam-Tong Leung, Eric W.-F. Lam, Ka-Fai To, Patrick Ming-Kuen Tang, Hui-Yao Lan
Journal nameAdvanced Science
Year2022
Month1
Day5
Volume Number9
Issue Number1
Article number2270005
eISSN2198-3844
LanguagesEnglish-United Kingdom
