Antimicrobial peptides towards clinical application: delivery and formulation
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AbstractAntimicrobial peptides hold promise to supplement small molecules antibiotics and combat the multidrug resistant microbes. There are however technical hurdles towards the clinical applications, largely due to the inherent limitations of peptides including stability, cytotoxicity and bioavailability. Here we review recent studies concerning the delivery and formulation of antimicrobial peptides, by categorizing the different strategies as driven by physical interactions or chemical conjugation reactions, and carriers ranging from inorganic based ones (including gold, silver and silica based solid nanoparticles) to organic ones (including micelle, liposome and hydrogel) are covered. Besides, targeted delivery of antimicrobial peptides or using antimicrobial peptides as the targeting moiety, and responsive release of the peptides after delivery are also reviewed. Lastly, strategies towards the increase of oral bioavailability, from both physical or chemical methods, are highlighted. Altogether, this article provides a comprehensive review of the recent progress of the delivery and formulation of antimicrobial peptides towards clinical application.
Acceptance Date30/05/2021
All Author(s) ListCheng Wang, Tingting Hong, Pengfei Cui, Jianhao Wang, Jiang Xia
Journal nameAdvanced Drug Delivery Reviews
Year2021
Month8
Volume Number175
Article number113818
ISSN0169-409X
LanguagesEnglish-United States

Last updated on 2024-21-08 at 00:43