A reversible microarray immobilization strategy based on thiol-quinone reaction
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AbstractMicroarray technology has been widely applied in biomedical research. The key to microarray study is to develop efficient immobilization method. In this study, we designed a new reversible microarray immobilization method based on thiol-quinone reaction. A quinone-functionalized slide was fabricated through H2O2 treatment of dopamine-coated slides. Various thiol-containing molecules can be anchored onto the quinone-functionalized slides via thioether linker, which could be cleaved under H2O2 treatment to regenerate quinone groups on the surface. The highly versatile approach can be widely used for immobilization of various thiol-containing molecules.
All Author(s) ListLing Feng, Ping Wang, Yi Feng, Jie Zhang, Qingxin Chen, Yusheng Xie, Jingdong Luo, Jiang Xia, Shao Q.Yao, Hongyan Sun
Journal nameChinese Chemical Letters
Year2022
Month1
Volume Number33
Issue Number1
PublisherElsevier
Pages213 - 216
ISSN1001-8417
eISSN1878-5964
LanguagesEnglish-United States