Adhesive Hemostatic Hydrogel with Ultrafast Gelation Arrests Acute Upper Gastrointestinal Hemorrhage in Pigs
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AbstractUpper gastrointestinal (GI) hemorrhage is a common clinical emergency worldwide. Endoscopic hemostasis is the current first line treatment. Nevertheless, for patients with severe active bleeding and challenging anatomy, endoscopic management can be still difficult and usually requires a higher level of surgical expertise. A simple and effective method of endoscopic hemostasis is therefore in acute clinical demand. Herein a hemostatic hybrid hydrogel comprised of hyaluronic acid and polyethylene glycol stabilized by thiourea-catechol coupling and disulfide bonds is reported. The hybrid hydrogels exhibit enhanced mechanical properties, short gelation time, and good blood clotting ability compared with fibrin gels. The in vivo hemostatic efficacy is confirmed in a rat model of arterial bleeding, in which the rapid gelation of hybrid hydrogels after topical application effectively arrests blood loss with no rebleeding occurring during resuscitation when blood pressure approximately recovers to normal. A large animal study further demonstrates the efficacy of hybrid hydrogels to achieve endoscopic hemostasis against upper GI hemorrhage in pigs. Follow-up observations show that the hybrid hydrogels can remain adherent at the bleeding wound for 48 h, indicating the sustained hemostatic function in vivo. Collectively, this work demonstrates a promising hemostatic hydrogel for endoscopic hemostasis in upper GI hemorrhage.
All Author(s) ListXia XF, Xu XY, Wang B, Zhou D, Zhang WL, Xie X, Lai HS, Xue J, Rai A, Li Z, Peng X, Zhao PC, Bian LM, Chiu PWY
Journal nameAdvanced Functional Materials
Year2022
Month4
Volume Number32
Issue Number16
PublisherWILEY-V C H VERLAG GMBH
Article number2109332
ISSN1616-301X
LanguagesEnglish-United Kingdom
Keywordsadhesive hydrogels, endoscopy, hemostasis, upper gastrointestinal hemorrhage
Web of Science Subject CategoriesChemistry, Multidisciplinary;Chemistry, Physical;Nanoscience & Nanotechnology;Materials Science, Multidisciplinary;Physics, Applied;Physics, Condensed Matter;Chemistry;Science & Technology - Other Topics;Materials Science;Physics
