Psychiatric Morbidity in Dependent Z-drugs and Benzodiazepine Users
Publication in refereed journal


摘要Zolpidem/zopiclone (Z-drugs) and benzodiazepines (BDZs) have different profiles of comorbidity, but studies have seldom explored these differences. This study examined psychiatric comorbidity in patients dependent on Z-drugs or BDZs attending substance abuse clinics in Hong Kong. In this retrospective chart review, the medical records of 207 patients (117 on Z-drugs and 90 on BDZs) treated between January 2008 and August 2012 were analysed. Demographic data, patterns of substance misuse and comorbid psychiatric diagnoses were recorded. Patients dependent on Z-drugs were younger (40.5 ± 10.4 vs. 46.8 ± 11.6; p < 0.001), had an earlier age of onset of drug misuse (p = 0.047) and were more likely to currently use cough syrup (29.5 ± 12.1 vs. 33.6 ± 14.5; p = 0.009) than the BDZs dependent patients. Overall, the Z-drugs and BDZs groups had a similar frequency of comorbid psychotic disorders, mood disorders and anxiety disorders. Mood disorders were the most common comorbid psychiatric disorders. The zopiclone group had a significantly higher percentage of psychotic disorders than the zolpidem group (25.5 % vs. 0; p = 0.022). To summarize, patients with Z-drugs or BDZs dependence have similar psychiatric comorbidities, with depressive disorder the most common comorbidity. Zopiclone is more likely to be associated with psychotic disorders than zolpidem.
著者Yong Lin, Wai Kwong Tang, Hua Jun Liang, Alan Tang, Gabor S. Ungvari
期刊名稱International Journal of Mental Health and Addiction
頁次555 - 564
關鍵詞Zolpidem, Zopiclone, Benzodiazepines, Comorbidity, Psychotic disorders, Mood disorders

上次更新時間 2020-15-09 於 01:14