Hypopigmentation and Healthy Skin Promoting Effect of a Modified Qi Bai San
Refereed conference paper presented and published in conference proceedings


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AbstractIntroduction: Qi Bai San (QBS, 七 白散 ) is a traditional Chinese herbal formula used by ancient ladies for healthy
skin and whitening. Although it is a popular product in the market, it contains animal drug and toxic herbs which
are undesirable. There is also lack of scientific evidence towards its efficacy. Hence, the aim of this study was to
investigate whether a modified form of such classical herbal formula (containing dried rhizome of Atractylodes macrocephala 白术, dried sclerotium of Poria cocos 白茯苓, etc.) would exert beneficial effects on skin condition. Methods: MTT assay was performed to determine the non-cytotoxic concentration of this modified QBS water extract on murine B16 melanoma cells. Cellular melanogenesis and tyrosinase activity assays were used to assess the melanin content and tyrosinase activity, respectively, on α-melanocyte-stimulating hormone (MSH)-induced B16 cells. Collagenase inhibition assay was used to test if the extract could exert collagenase inhibitory activity. Results: The modified QBS extract (0.25–1 mg/ml) could significantly reduce α-MSH-induced increase in melanin content. This extract (0.5–1 mg/ml) could also dose-dependently reduce α-MSH-induced increase on tyrosinase activity, though not statistically significant. Besides, 1 mg/ml QBS extract significantly inhibited collagenase activity. Conclusion: We showed for the first time that a modified QBS formula could exert dose-dependent hypopigmentation and collagenase inhibitory effects. These in vitro data provided scientific evidence supporting the efficacy of this formula on hypopigmentation and healthy skin promotion.
All Author(s) ListWAT Chi Ling Elaine, CHAN Yau Tsz, TSO Tiffany Hoi Ka, NG Chun Fai, LAU Ching Po, SIU Wing Sum, KO Chun Hay, LAU K. K., HU R., LAU Bik San Clara, LEUNG Ping Chung
Name of Conference5th Annual Meeting of GP-TCM Research Association-cum-Summit on Compendium of Materia Medica and Innovative Drug Discovery in Chinese Medicine
Start Date of Conference09/08/2016
End Date of Conference10/08/2016
Place of ConferenceHong Kong
Country/Region of ConferenceChina
Proceedings Title5th Annual Meeting of GP-TCM Research Association-cum-Summit on Compendium of Materia Medica and Innovative Drug Discovery in Chinese Medicine
Year2016
Month8
Day9
Place of PublicationChina, Hong Kong
Pages1
LanguagesEnglish-United Kingdom

Last updated on 2018-22-01 at 12:57